FG-2216
货号：
18382-25mg 基本售价：
8330.0 元 规格：
25 mg
产品信息
概述| 货号 | 18382-25mg |
| 描述 | Hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) enzymes act as central gatekeepers of post-transcriptional and transcriptional adaptation to hypoxia, oxidative stress, and excitotoxicity. FG-2216 is an orally active PHD2 inhibitor (IC50 = 3.9 µM) that stabilizes HIF-α.1 It has been shown to reversibly stimulate erythropoietin secretion at 100 µM in vitro and to increase hematocrit, red blood cell count, and hemoglobin levels at 50 mg/kg in mice.1,2 |
| 别名 | IOX3;YM-311; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hong, Y.R.,Kim, H.T.,Lee, S.L., et al. [(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)-amino]-acetic acid derivatives; HIF prolyl 4-hydroxylase inhibitors as oral erythropoietin secretagogues. Bioorganic & Medicinal Chemistry 23(21), 5953-5957 (2013).
2.Hsieh, M.M.,Linde, N.S.,Wynter, A., et al. HIF-prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaque. Blood 110(6), 2140-2147 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 280.7 |
| 分子式 | C12H9ClN2O4 |
| CAS号 | 223387-75-5 |
| 稳定性 | ≥ 2 years |
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