CV-6209 (chloride)
货号：
15955-5mg 基本售价：
8302.0 元 规格：
5 mg
产品信息
概述| 货号 | 15955-5mg |
| 描述 | CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor, inhibiting aggregation of rabbit and human platelets induced by PAF with IC50 values of 75 and 170 nM, respectively.1 It has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen.1 CV-6209 is bioavailable, as it prevents PAF-induced hypotension in rats, while not blocking hypotension triggered by arachidonic acid (Item No. 90010), histamine, bradykinin (Item No. 15539), or isoproterenol (Item No. 15592).1 CV-6209 is used to study the role of PAF receptor signaling in vitroandin vivo.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Terashita, Z.,Imura, Y.,Takatani, M., et al. CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo. Journal of Pharmacology and Experimental Therapeutics 242, 263-268 (1987).
2.Leong, H.S.,Mahesh, B.M.,Day, J.R., et al. Vimentin autoantibodies induce platelet activation and formation of platelet-leukocyte conjugates via platelet-activating factor. Journal of Leukocyte Biology 83(2), 263-271 (2008).
3.Musio, S.,Pedotti, P.,Mantegazza, R., et al. Anaphylaxis to a self-peptide in the absence of mast cells or histamine. Laboratory Investigation 89(4), 398-405 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 642.3 |
| 分子式 | C34H60N3O6 • Cl |
| CAS号 | 100488-87-7 |
| 稳定性 | ≥ 2 years |
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