| 货号 | 10011348-5mg |
| 描述 | Taprostene is a stable prostacyclin (PGI2) analog and agonist of the prostacyclin receptor, IP. It does not activate the PGE2 receptor EP4,1 which, like IP, promotes vascular smooth muscle relaxation when stimulated. Taprostene has been used extensively to study the role of the IP receptor in tissue preparations1,2andin vivo.3,4 It has also been used in the screening and evaluation of potential IP antagonists.5 |
| 别名 | CG 4203;Rheocyclan; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jones, R.L. and Chan, K.m. Distinction between relaxations induced via prostanoid EP4 and IP1 receptors in pig and rabbit blood vessels. British Journal of Pharmacology 134, 313-324 (2001). 2.Tam, F.S.F.,Chan, K.m.,Bourreau, J.P., et al. The mechanisms of enhancement and inhibition of field stimulation responses of guinea-pig vas deferens by prostacyclin analogues. British Journal of Pharmacology 121, 1413-1421 (1997). 3.Virgolini, I.,Fitscha, P.,Sinzinger, H., et al. Effects of taprostene, a stable prostacyclin analogue, on haemodynamics, platelet function and arachidonate metabolism in healthy volunteers. European Journal of Clinical Pharmacology 38, 347-350 (1990). 4.Johnson, G., III,Furlan, L.E.,Aoki, N., et al. Endothelium and myocardial protecting actions of taprostene, a stable prostacyclin analogue, after acute myocardial ischemia and reperfusion in cats. Circulation Research 66, 1362-1370 (1990). 5.Ayer, L.M.,Wilson, S.M.,Traves, S.L., et al. 4,5-dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine (RO1138452) is a selective, pseudo-irreversible orthosteric antagonist at the prostacyclin (IP)-receptor expressed by human airway epithelial cells: IP-receptor-mediated inhibition of CXCL9 and CXCL10 release. Journal of Pharmacology and Experimental Therapeutics 324(2), 815-826 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 398.5 |
| 分子式 | C24H30O5 |
| CAS号 | 108945-35-3 |
| 稳定性 | ≥ 1 year |
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