FSLLRY-amide
货号：
14709-25mg 基本售价：
8260.0 元 规格：
25 mg
产品信息
概述| 货号 | 14709-25mg |
| 描述 | FSLLRY-amide is a peptide antagonist of protease-activated receptor (PAR) 2 which blocks activation by trypsin (IC50 = ~50 μM) but not by the synthetic agonist SLIGRL-NH2 (Item No. 16723).1 It does not affect thrombin-induced activation of PAR1 or trypsin-mediated proteolysis of casein.1 It can be used to study PAR2 action in cells and in animals.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Al-Ani, B.,Saifeddine, M.,Wijesuriya, S.J., et al. Modified proteinase-activated receptor-1 and -2 derived peptides inhibit proteinase-activated receptor-2 activation by trypsin. Journal of Pharmacology and Experimental Therapeutics 300(2), 702-708 (2002).
2.McLarty, J.L.,Meléndez, G.C.,Brower, G.L., et al. Tryptase/protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts. Hypertension 58(2), 264-270 (2011).
3.Chen, Y.,Yang, C. and Wang, Z.J. Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain. Neuroscience 193, 440-451 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 797 |
| 分子式 | C39H60N10O8 |
| CAS号 | 245329-02-6 |
| 稳定性 | ≥ 2 years |
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