| 货号 | 15382-5mg |
| 描述 | Enniatins are cyclichexadepsipeptides commonly isolated from fungi. Many act as ionophores, forming pores in cellular membranes to allow selective ion transport.1 Enniatin B is a relatively poor ionophore with some capacity to facilitate import of K+ and Na+ across membranes.2 It inhibits the pleiotropic drug resistance protein 5 (Pdr5p) in yeast.3 Through this mechanism enniatin B, at concentrations as low as 0.8 μM, augments the ability of cerulenin (Item No. 10005647) or cycloheximide (Item No. 14126) to impair cell proliferation in cells overexpressing Pdr5p, an effect that is not observed in cells lacking Pdr5p.3 Like other enniatins, enniatin B inhibits acyl-CoA: cholesterol acyltransferase (IC50 = 113 μM), blocking cholesteryl ester formation.4 Enniatin B (1 μM) also increases caspase activity and induces apoptosis in H4IIE hepatoma cells and, when mixed with other enniatins, alters p53 signaling in human cancer cells.5,6 |
| 别名 | Antibiotic 86/88; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sy-Cordero, A.A.,Pearce, C.J. and Oberlies, N.H. Revisiting the enniatins: A review of their isolation, biosynthesis, structure determination and biological activities. J.Antibiot.(Tokyo) 65(11), 541-549 (2012). 2.Kamyar, M.R.,Rawnduzi, P.,Studenik, C.R., et al. Investigation of the electrophysiological properties of enniatins. Archives of Biochemistry and Biophysics 429(2), 215-223 (2004). 3.Hiraga, K.,Yamamoto, S.,Fukuda, H., et al. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Biochemical and Biophysical Research Communications 328(4), 1119-1125 (2005). 4.Tomoda, H.,Huang, X.H.,Cao, J., et al. Inhibition of acyl-CoA: Cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J.Antibiot.(Tokyo) 45(10), 1626-1632 (1992). 5.Wätjen, W.,Debbab, A.,Hohlfeld, A., et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol.Nutr.Food Res. 53(4), 431-440 (2009). 6.Dornetshuber, R.,Heffeter, P.,Kamyar, M.R., et al. Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells. Chemical Research in Toxicology 20(3), 465-473 (2007). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 639.8 |
| 分子式 | C33H57N3O9 |
| CAS号 | 917-13-5 |
| 稳定性 | ≥ 2 years |
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