| 货号 | 16339-100mg |
| 描述 | 7-keto Cholesterol is a bioactive sterol that can affect cholesterol homeostasis, membrane properties and cell survival.1,2 It strongly inhibits cytochrome P450 7A1 (CYP7A1), the cholesterol 7α-hydroxylase, with an IC50 = ~ 1 µM.2 7-keto Cholesterol can be produced by oxidation of cholesterol associated with ethanol-mediated lipid peroxidation or photodamage.3,4,5 It can also be derived enzymatically by oxidation of 7-dehydrocholesterol, the immediate precursor of cholesterol, by CYP7A1, while 11β-hydroxysteroid dehydrogenase type 1 stimulates its reduction.2,6 7-keto Cholesterol is a major oxysterol component of oxidized LDL.1,7 This compound can be used as a standard in the determination of cholesterol derivatives by GC-MS or HPLC. |
| 别名 | Δ5-Cholesterol-3β-ol-7-one;7-oxo Cholesterol;SC-4722; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Shentu, T.P.,Titushkin, I.,Singh, D.K., et al. oxLDL-induced decrease in lipid order of membrane domains is inversely correlated with endothelial stiffness and network formation. American Journal of Physiology.Cell Physiology 299(2), C218-C229 (2010). 2.Shinkyo, R.,Xu, L.,Tallman, K.A., et al. Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate. The Journal of Biological Chemisty 286(38), 33021-33028 (2011). 3.Adachi, J.,Kudo, R.,Ueno, Y., et al. Heart 7-hydroperoxycholesterol and oxysterols are elevated in chronically ethanol-fed rats. Journal of Nutrition 131(11), 2916-2920 (2001). 4.Nakagawa, K.,Adachi, J.,Wong, M.C., et al. Protective effect of daidzein against acute ethanol-induced lipid peroxidation in rat jejunum. Kobe J.Med.Sci. 52(5), 141-149 (2006). 5.Rodriguez, I.R. and Fliesler, S.J. Photodamage generates 7-keto- and 7-hydroxycholesterol in the rat retina via a free radical-mediated mechanism. Photochemistry and Photobiology 85(5), 1116-1125 (2009). 6.Mitic, T.,Shave, S.,Semjonous, N., et al. 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo. Biochemical Pharmacology 86(1), 146-153 (2013). 7.Brown, A.J.,Leong, S.l.,Dean, R.T., et al. 7-Hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque. Journal of Lipid Research 38, 1730-1745 (1997). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 400.6 |
| 分子式 | C27H44O2 |
| CAS号 | 566-28-9 |
| 稳定性 | ≥ 2 years |
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