| 货号 | 15779-10mg |
| 描述 | Oseltamivir (GS-4104) is an antiviral prodrug targeted against the influenza viruses.1,2 Oseltamivir acid is the active metabolite of oseltamivir.3,4 It acts as an inhibitor of influenza neuraminidases A and B (IC50 = 0.1 to 4.9 nM for both enzymes), in this way preventing virus budding and release.5,6,7 |
| 别名 | GS-4071;Ro 64-0802; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sidwell, R.W.,Huffman, J.H.,Barnard, D.L., et al. Inhibition of influenza virus infections in mice by GS4104, an orally effective influenza virus neuraminidase inhibitor. Antiviral Res. 37(2), 107-120 (1998). 2.Hayden, F.G.,Atmar, R.L.,Schilling, M., et al. Use of the selective oral neuraminidase inhibitor oseltamivir to prevent influenza. New England Journal of Medicine 341(18), 1336-1343 (1999). 3.Li, W.,Escarpe, P.S.,Eisenberg, E.J., et al. Identification of GS 4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS 4071. Antimicrobial Agents and Chemotherapy 42(3), 647-653 (1998). 4.Oliyai, R.,Yuan, L.C.,Dahl, T.C., et al. Biexponential decomposition of a neuraminidase inhibitor prodrug (GS-4104) in aqueous solution. Pharmaceutical Research 15(8), 1300-1304 (1998). 5.Govorkova, E.A.,Ilyushina, N.A.,McClaren, J.L., et al. Susceptibility of highly pathogenic H5N1 influenza viruses to the neuraminidase inhibitor oseltamivir differs in vitro and in a mouse model. Antimicrobial Agents and Chemotherapy 53(7), 3088-3096 (2009). 6.Krueger, A.C.,Xu, Y.,Kati, W.M., et al. Synthesis of potent pyrrolidine influenza neuraminidase inhibitors. Bioorganic & Medicinal Chemistry Letters 18(5), 1692-1695 (2008). 7.Lew, W.,Wu, H.,Chen, X., et al. Carbocyclic influenza neuraminidase inhibitors possessing a C3-cyclic amine side chain: Synthesis and inhibitory activity. Bioorganic & Medicinal Chemistry Letters 10(11), 1257-1260 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 284.4 |
| 分子式 | C14H24N2O4 |
| CAS号 | 187227-45-8 |
| 稳定性 | ≥ 2 years |
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