PPQ-102
货号：
16275-50mg 基本售价：
8176.0 元 规格：
50 mg
产品信息
概述| 货号 | 16275-50mg |
| 描述 | The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). PPQ-102 is a cell-permeable pyrimido-pyrrolo-quinoxalinedione that reversibly inhibits CFTR chloride channels with an IC50 value of 90 nM.1 At 0.5-5 µM, PPQ-102 has been used to reduce the size and number of renal cysts in a neonatal kidney organ culture model of polycystic kidney disease.1 At 1 µM, PPQ-102 can increase vascular endothelial growth factor-A production in cultured airway epithelial NCI-H292 cells, triggering epidermal growth factor receptor phosphorylation.2 |
| 别名 | CFTR Inhibitor IV;Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tradtrantip, L.,Sonawane, N.D.,Namkung, W., et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J.Med.Chem 52(20), 6447-6455 (2009).
2.Martin, C.,Coolen, N.,Wu, Y., et al. CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epithelium. European Respiratory Journal 42, 1553-1562 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 438.5 |
| 分子式 | C26H22N4O3 |
| CAS号 | 931706-15-9 |
| 稳定性 | ≥ 2 years |
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