4-iodo-SAHA
货号：
10495-500mg 基本售价：
8064.0 元 规格：
500 mg
产品信息
概述| 货号 | 10495-500mg |
| 描述 | 4-iodo-SAHA is a hydrophobic derivative of the class I and class II histone deacetylase (HDAC) inhibitor SAHA. At 1 μM it demonstrates >60% inhibition of HDAC1 and HDAC6 activity in a deacetylase activity assay, similar to that of SAHA. 4-iodo-SAHA inhibits proliferation of SK-BR-3 breast-derived and HT29 colon-derived cell lines with EC50 values comparable to that of SAHA (1.1 and 0.95 μM versus 2.1 and 2 μM, respectively). It is 10-fold more potent as an inhibitor of U937 leukemia cell proliferation compared to SAHA (0.12 μM versus 1.2 μM, respectively).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Salmi-Smail, C.,Fabre, A.,Dequiedt, F., et al. Modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity. Journal of Medicinal Chemistry 53, 3038-3047 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 390.2 |
| 分子式 | C14H19IN2O3 |
| CAS号 | 1219807-87-0 |
| 稳定性 | ≥ 2 years |
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