PIK-III
货号：
17002-25mg 基本售价：
8050.0 元 规格：
25 mg
产品信息
概述| 货号 | 17002-25mg |
| 描述 | PIK-III is an inhibitor of the type 3 phosphatidylinositol 3-kinase (PI3K) vacuolar protein sorting 34 (Vps34) that binds a unique hydrophobic pocket (IC50 = 18 nM).1 It is selective for Vps34 over related PI3K isoforms, PI4Kβ, and mTOR. PIK-III acutely inhibits autophagy and de novo lipidation of LC3, leading to stabilization of autophagy substrates.1 |
| 别名 | Vacuolar Protein Sorting 34 Inhibitor 2;Vps34-IN2;Vps34 Inhibitor 2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Dowdle, W.E.,Nyfeler, B.,Nagel, J., et al. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat.Cell.Biol. 16(11), 1069-1079 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 319.4 |
| 分子式 | C17H17N7 |
| CAS号 | 1383716-40-2 |
| 稳定性 | ≥ 2 years |
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