Enniatin A1
货号：
17457-5mg 基本售价：
8036.0 元 规格：
5 mg
产品信息
概述| 货号 | 17457-5mg |
| 描述 | Enniatins are cyclohexadepsipeptides commonly isolated from fungi that are known to have antibiotic properties and to induce apoptosis in several cancer lines.1 Many function as ionophores, forming pores in cellular membranes to allow selective ion transport.1,2 Enniatin A1 is one of four major analogs in the enniatin complex (Item No. 9002040 class). Its ionophoric activity has been described.2 Additionally, enniatin A1 has been found to induce apoptosis in cancer cells (EC50 = 5 µM in H4IIE rat hepatoma cells), decreasing the activation of the cell proliferation kinase, ERK (p44/p42) and inhibiting TNF-α-induced NF-κB activation.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sy-Cordero, A.A.,Pearce, C.J. and Oberlies, N.H. Revisiting the enniatins: A review of their isolation, biosynthesis, structure determination and biological activities. J.Antibiot.(Tokyo) 65(11), 541-549 (2012).
2.Kamyar, M.R.,Rawnduzi, P.,Studenik, C.R., et al. Investigation of the electrophysiological properties of enniatins. Archives of Biochemistry and Biophysics 429(2), 215-223 (2004).
3.Wätjen, W.,Debbab, A.,Hohlfeld, A., et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol.Nutr.Food Res. 53(4), 431-440 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 667.9 |
| 分子式 | C35H61N3O9 |
| CAS号 | 4530-21-6 |
| 稳定性 | ≥ 2 years |
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