货号 | 5284/50 |
别名 | N,N'-trans-1,4-cyclohexanediylbis[2- |
供应商 | Tocris |
生物活性 | Integrated stress response (ISR) inhibitor; reverses the effects of eIF2α phosphorylation (IC50 = 5 nM) and restores cell translation capacity. Acts downstream of PERK, targeting interactions between eIF2α kinases and elF2B. Blocks ATF4 production without altering the IRE1 or ATF6 responses in vitro. Displays memory enhancement in hippocampus-dependent spatial and fear-associated learning in rodents. Brain penetrant. |
运输条件 | Blue Ice |
存放说明 | 4℃ |
纯度 | >99 % |
计算分子量 | 451.34 |
分子式 | C22H24Cl2N2< |
可溶性/溶解性 | Soluble to 10 mM in DMSO with gentle warming |
参考文献 | Hinnebusch (2015) Cell biology. Blocking stress response for better memory? Science 348 967. PMID: 26023119. Sekineet al (2015) Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound. Science 348 1027. PMID: 25858979. Sidrauskiet al (2013) Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife 2 e00498. PMID: 23741617. |