| 货号 | 2946/50 |
| 别名 | 1-[(2-Chlorophenyl)diphenylmethyl]- |
| 供应商 | Tocris |
| 生物活性 | Potent and highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 344.84 |
| 分子式 | C22H17ClN2 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO with gentle warming |
| CAS号 | 289905-88-0 |
| 参考文献 | Schilling and Eder (2007) TRAM-34 inhibits nonselective cation channels. Pflugers Arch. 454 559. PMID: 17318643. Wanget al (2007) An intermediate-conductance Ca2+-activated K+ channel mediates B lymphoma cell cycle progression induced by serum. Pflugers Arch. 454 945. PMID: 17429684. Wulffet al (2000) Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc.Natl.Acad.Sci. USA 978151. |