| 货号 | 2004/50 |
| 别名 | 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-di |
| 供应商 | Tocris |
| 生物活性 | Potent and selective L-type voltage-gated Ca2+ channel blocker. EC50 and pA2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca2+-induced contractions of rabbit aorta respectively; EC25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo, exerting primary effects on vascular tissue with secondary negative chronotropic action. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 371.39 |
| 分子式 | C19H21N3O5 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 20 mM in ethanol |
| CAS号 | 75695-93-1 |
| 参考文献 | Ruegg and Hof (1990) Pharmacology of the calcium antagonist isradipine. Drugs 403. Wadaet al (1985) Separation of the coronary vasodilator from the cardiac effects of PN 200-110, a new dihydropyridine calcium antagonist, in the dog heart. J.Cardiovasc.Pharmacol. 7 190. PMID: 2580142. Hofet al (1984) PN 200-110, a new calcium antagonist: electrophysiological, inotropic, and chronotropic effects on guinea pig myocardial tissue and effects on contraction and calcium uptake of rabbit aorta. J.Cardiovasc.Pharmacol. 6 399. PMID: 6202964. |