| 货号 | 1494/50 |
| 别名 | 2,3-bis(4-Hydroxyphenyl)-propionitr |
| 供应商 | Tocris |
| 生物活性 | Highly potent estrogen ERβ receptor agonist with a 70-fold selectivity over ERα(EC50 values are 0.85 and 66 nM respectively). Relaxes mesenteric arteries in vitro. Shown to regulate expression of GluR1, GluR2 and GluR3 in rat hippocampus. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 239.27 |
| 分子式 | C15H13NO2 |
| 可溶性/溶解性 | Soluble to 30 mM in 1eq. NaOH and to 100 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 1428-67-7 |
| 参考文献 | Waterset al (2009) Estrogen receptor alpha and beta specific agonists regulate expression of synaptic proteins in rat hippocampus. Brain Res. 1290 1. PMID: 19596275. Harringtonet al (2003) Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression. Mol.Cell.Endocrinol. 206 13. PMID: 12943986. Montgomeryet al (2003) Acute effects of oestrogen receptor subtype-specific agonists on vascular contractility. Br.J.Pharmacol. 139 1249. PMID: 12890703. Meyerset al (2001) Estrogen receptor-β potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J.Med.Chem. 44 4230. PMID: 11708925. |