| 货号 | 3837/50 |
| 别名 | [N-(4-Chlorophenyl)]-α-[(4-chlorophe |
| 供应商 | Tocris |
| 生物活性 | Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). Evokes positive modulation of acetylcholine (ACh)-induced EC5 currents (EC50 = 0.7 μM). Exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 388.25 |
| 分子式 | C19H15Cl2N3O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| CAS号 | 917837-54-8 |
| 参考文献 | Huet al (2009) Positive allosteric modulation of α7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons. Br.J.Pharmacol. 158 1857. PMID: 20050184. Gronlienet al (2007) Distinct profiles of α7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. Mol.Pharmacol. 72 715. PMID: 17565004. Nget al (2007) Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc.Natl.Acad.Sci. 1048059. |