| 货号 | 16782-10mg |
| 描述 | Fluprostenol is a well-studied, potent analog of prostaglandin F2α(PGF2α) and acts primarily through the FP receptor.1 Oxidation at C-9 of fluprostenol yields 9-keto fluprostenol. Prostaglandin esters are known to be hydrolyzed in the eye to the corresponding free acids.2 However, the use of prostaglandin esters as prodrugs outside the eye is relatively unexplored. 9-keto Fluprostenol is an analog of PGE2 with structural modifications intended to give it a prolonged half-life and greater potency. 9-keto Fluprostenol isopropyl ester has the potential to act as an EP agonist in prodrug form. However, no studies on the pharmacology of this compound have been published to date. In addition 9-keto fluprostenol isopropyl ester is a potential metabolite of Travoprost, which is the Alcon trade name for fluprostenol isopropyl ester. In monkey cornea, this transformation was observed as a product of NADP+-dependent 15-hydroxyprostaglandin dehydrogenase when the closely related analog Latanoprost was used as a substrate.3 Certain F-series prostaglandins have been shown to be converted to the corresponding E-series compounds in rabbit liver4 and human platelet5preparations. |
| 别名 | Fluprostenol Prostaglandin E2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Dukes, M.,Russell, W. and Walpole, A.L. Potent luteolytic agents related to prostaglandin F2α. Nature 250, 330-331 (1974). 2.Goh, Y. and Kishino, J. Pharmacological characterization of prostaglandin-related ocular hypotensive agents. Japanese Journal of Ophthamology 38, 236-245 (1994). 3.Fujimori, K.,Okada, T. and Urade, Y. Expression of NADP+-dependent 15-hydroxyprostaglandin dehydrogenase mRNA in monkey ocular tissues and characterization of its recombinant enzyme. Journal of Biochemistry 131, 383-389 (2002). 4.Wong, P.Y.K.,Malik, K.U.,Desiderio, D.M., et al. Hepatic metabolism of prostacyclin (PGI2) in the rabbit: Formation of a potent novel inhibitor of platelet aggregation. Biochemical and Biophysical Research Communications 93, 486-494 (1980). 5.Wong, P.Y.K.,Lee, W.H.,Chao, P.H.W., et al. Metabolism of prostacyclin by 9-hydroxyprostaglandin dehydrogenase in human platelets. Formation of a potent inhibitor of platelet aggregation and enzyme purification. The Journal of Biological Chemisty 255(19), 9021-9024 (1980). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 498.5 |
| 分子式 | C26H33F3O6 |
| CAS号 | 1219032-18-4 |
| 稳定性 | ≥ 2 years |
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