Autocamtide-2-related Inhibitory Peptide
货号：
17590-10mg 基本售价：
7882.0 元 规格：
10 mg
产品信息
概述| 货号 | 17590-10mg |
| 描述 | Autocamtide-2-related inhibitory peptide is a calmodulin-dependent protein kinase II (CaMKII) inhibitor (IC50 = 40 nM) that was designed based on the sequence around the autophosphorylation site (Thr286/Thr287) in the autoinhibitory domain of the protein kinase.1,2 It is nonphosphorylatable and selective for CaMKII over PKC, PKA and CaMKIV (IC50s > 10 μM).1,2 This compound is a useful tool for studying the physiological roles of CaMKII.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ishida, A.,Kameshita, I.,Okuno, S., et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochemical and Biophysical Research Communications 212(3), 806-812 (1995).
2.Ishida, A. and Fujisawa, H. Stabilization of calmodulin-dependent protein kinase II through autoinhibitory domain. The Journal of Biological Chemisty 270(5), 2163-2170 (1995).
3.Takasawa, S.,Ishida, A.,Nata, K., et al. Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca2+ mobilization. The Journal of Biological Chemisty 270(51), 30257-30259 (1995).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1611.8 |
| 分子式 | C64H116N22O19 • CF3COOH |
| 稳定性 | ≥ 2 years |
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