| 货号 | 14579-50mg |
| 描述 | Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.1,2 Purvalanol A reversibly arrests synchronized cells in the G1 and G2 phase of the cell cycle, inhibiting both cell proliferation and cell death.3 At 10 μM, purvalanol A potently suppresses the anchorage-independent growth of c-Src-transformed cells as well as HT-29 and SW48 human colon cancer cells.4 |
| 别名 | NG 60; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Gray, N.S.,Wodicka, L.,Thunnissen, A.M.W.H., et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281, 533-538 (1998). 2.Bain, J.,McLauchlan, H.,Elliot, M., et al. The specificities of protein kinase inhibitors: An update. Biochemistry Journal 371, 199-204 (2003). 3.Villerbu, N.,Gaben, A.M.,Redeuilh, G., et al. Cellular effects of purvalanol A: A specific inhibitor of cyclin-dependent kinase activities. International Journal of Cancer 97, 761-769 (2002). 4.Hikita, T.,Oneyama, C. and Okada, M. Purvalanol A, a CDK inhibitor, effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src. Genes to Cells 15, 1051-1062 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 388.9 |
| 分子式 | C19H25ClN6O |
| CAS号 | 212844-53-6 |
| 稳定性 | ≥ 2 years |
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