Tiotropium (bromide)
货号：
15773-50mg 基本售价：
7854.0 元 规格：
50 mg
产品信息
概述| 货号 | 15773-50mg |
| 描述 | Tiotropium is a long-acting muscarinic receptor antagonist used as a bronchodilator in the treatment of chronic obstructive pulmonary disease.1,2 It binds equally to human muscarinic M1, M2, and M3 receptors (Kds = 0.04, 0.02, and 0.01 nM, respectively), dissociating slowly from M1 and M3 receptors, which are located on bronchial smooth muscle and submucosal glands, and more rapidly from M2 receptors (t½ = 14.6 and 34.7 versus 3.6 hours, respectively).3 |
| 别名 | BA 679BR;Spiriva®;Tiova; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tashkin, D.P. and Ferguson, G.T. Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease. Respiratory Research 14, 49 (2013).
2.Maesen, F.P.,Smeets, J.J.,Sledsens, T.J., et al. Tiotropium bromide, a new long-acting antimuscarinic bronchodilator: A pharmacodynamic study in patients with chronic obstructive pulmonary disease (COPD). European Respiratory Journal 8(9), 1506-1513 (1995).
3.Barnes, P.J. The pharmacological properties of tiotropium. Chest 117(2 Suppl), 63S-66S (2000).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 472.4 |
| 分子式 | C19H22NO4S2 • Br |
| CAS号 | 136310-93-5 |
| 稳定性 | ≥ 2 years |
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