Salermide
货号：
13178-100mg 基本售价：
7840.0 元 规格：
100 mg
产品信息
概述| 货号 | 13178-100mg |
| 描述 | The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation that is relevant to, e.g., longevity, cancer, gene regulation, energy homeostasis, and apoptosis.1,2 Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death.3 In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~ 20 μM) by reactivating proapototic genes that are repressed by SIRT1.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yamamoto, H.,Schoonjans, K., and Auwerx, J. Sirtuin functions in health and disease. Molecular Endocrinology 21(8), 1745-1755 (2007).
2.Milne, J.C., and Denu, J.M. The sirtuin family:Therapeutic targets to treat diseases of aging. Current Opinion in Chemical Biology 12, 11-17 (2008).
3.Lara, E.,Mai, A.,Calvanese, V., et al. Salermide, a sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 394.5 |
| 分子式 | C26H22N2O2 |
| CAS号 | 1105698-15-4 |
| 稳定性 | ≥ 2 years |
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