| 货号 | 13000-500mg |
| 描述 | Pterostilbene is a naturally-occurring dimethyl ether analog of resveratrol that is abundant in blueberries. Like resveratrol, pterostilbene acts as a powerful antioxidant, suppresses the synthesis of prostaglandin E2 from lipopolysaccharide-stimulated human peripheral blood mononuclear cells (IC50 = 1.0 μM for pterostilbene, 3.2 μM for resveratrol), and inhibits cell proliferation (IC50 = ~60 μM for both compounds).1,2,3 Pterostilbene blocks the activation of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways, reducing NF-κB and AP-1 transcriptional activation.4,5,6 Through these actions, pterostilbene evokes effects that prevent cancer, inflammation, and diabetes. |
| 别名 | 3,5-Dimethoxy-4-Stilbenol;trans-3,5-Dimethoxy-4-Hydroxystilbene; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rimando, A.M.,Cuendet, M.,Desmarchelier, C., et al. Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. Journal of Agricultural and Food Chemistry 50, 3453-3457 (2002). 2.Stivala, L.A.,Savio, M.,Carafoli, F., et al. Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol. The Journal of Biological Chemisty 276(25), 22586-22594 (2001). 3.Hougee, S.,Faber, J.,Sanders, A., et al. Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers. Planta Medica 71, 387-392 (2005). 4.Pan, M.H.,Chang, Y.H.,Tsai, M.L., et al. Pterostilbene suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages. Journal of Agricultural and Food Chemistry 56, 7502-7509 (2008). 5.Pan, M.H.,Lin, Y.T.,Lin, C.L., et al. Suppression of heregulin-ß1/HER2-modulated invasive and aggressive phenotype of breast carcinoma by pterostilbene via inhibition of matrix metalloproteinase-9, p38 kinase cascade and Akt activation. Evidence-Based Complementary and alternative Medicine (2009). 6.Pan, M.H.,Chiou, Y.S.,Chen, W.J., et al. Pterostilbene inhibited tumor invasion via suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells. Carcinogenesis 30(7), 1234-1242 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 256.3 |
| 分子式 | C16H16O3 |
| CAS号 | 537-42-8 |
| 稳定性 | ≥ 2 years |
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