| 货号 | 1129/50 |
| 别名 | 5-Hydroxy-3-(1-methylpiperidin-4-yl |
| 供应商 | Tocris |
| 生物活性 | A potent 5-ht1E/1F receptor agonist (pEC50 values are 8.5 and 8.6 respectively). Displays > 30-fold selectivity over other 5-HT and dopamine receptors (pKi values are 8.7. 8.9, 7.2, 6.9, 7.2, 5.9, 7.0, 6.5, < 6, < 6, 6.3 and 6.2 for human 5-HT1E,1F,1A,1B,1D,2A,2B,2C,4,7, D2 and D3 receptors respectively). Induces 5-HT2A receptor-mediated mouse aortic contraction in vitro(pEC50 = 6.52). Active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 230.31 |
| 分子式 | C14H18N2O |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | McKune and Watt (2001) Characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. J.Pharmacol.Exp.Ther. 297 88. PMID: 11259531. Brownet al (1998) BRL 54443, a potent agonist with selectivity for human cloned 5-HT1E and 5-HT1F receptors. Br.J.Pharmacol. 123233P. Lightowleret al (1998) Effect of BRL 54443 (3-(1-methylpiperidin-4-yl)-1H-indol-5-ol), a 5-HT1E/1F receptor agonist, on general behaviour and maximal electroshock seizure threshold in the rat. Br.J.Pharmacol. 123237P. |