| 货号 | 34250-250ug |
| 描述 | 5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils by a specific dehydrogenase.1 It stimulates cytosolic calcium levels in neutrophils with an EC50 value of 2 nM.2 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway in stimulated neutrophils via a specific G protein-coupled receptor.3,4,5,6 |
| 别名 | 5-KETE; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Powell, W.S.,Gravelle, F., and Gravel, S. Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytes. The Journal of Biological Chemisty 267, 19233-19241 (1992). 2.Powell, W.S.,Zhang, Y., and Gravel, S. Effects of phorbol myristate acetate on the synthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid by human polymorphonuclear leukocytes. Biochemistry 33, 3927-3933 (1994). 3.OFlaherty, J.T.,Kuroki, M.,Nixon, A.B., et al. 5-Oxo-eicosanoids and hematopoietic cytokines cooperate in stimulating neutrophil function and the mitogen-activated protein kinase pathway. The Journal of Biological Chemisty 271, 17821-17828 (1996). 4.OFlaherty, J.T.,Kuroki, M.,Nixon, A.B., et al. 5-Oxo-eicosatetraenoate is a broadly active, eosinophil-selective stimulus for human granulocytes. Journal of Immunology 157, 336-342 (1996). 5.Hosoi, T.,Koguchi, Y.,Sugikawa, E., et al. Identification of a novel human eicosanoid receptor coupled to Gi/o. The Journal of Biological Chemisty 277 (35), 31459-31465 (2002). 6.Jones, C.E.,Holden, S.,Tenaillon, L., et al. Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils. Molecular Pharmacology 63(3), 471-477 (2003). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% |
| 计算分子量 | 318.5 |
| 分子式 | C20H30O3 |
| CAS号 | 106154-18-1 |
| 稳定性 | ≥ 1 year |
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