PF-04981517
货号：
15019-50mg 基本售价：
7728.0 元 规格：
50 mg
产品信息
概述| 货号 | 15019-50mg |
| 描述 | Cytochrome P450 (CYP450) isozyme CYP3A4 is an important drug-metabolizing enzyme.1 PF-04981517 is a potent, time-dependent inhibitor of CYP3A4 (IC50 = 30 nM).2 It is less effective against CYP3A5 and CYP3A7 (IC50s = 17 and 70 μM, respectively).2 PF-04981517 will be useful for understanding the relative roles of CYP3A4 and CYP3A5 in drug metabolism. |
| 别名 | CYP3cide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bibi, Z. Role of cytochrome P450 in drug interactions. Nutrition & Metabolism 5(27), 1-10 (2008).
2.Walsky, R.L.,Obach, R.S.,Hyland, R., et al. Selective mechanism-based inactivation of cytochrome P4503A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of cytochrome P4503A4 versus P4503A5 in the metabolism of drugs. Drug Metabolism and Disposition 40(9), 1686-1697 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 456.6 |
| 分子式 | C26H32N8 |
| CAS号 | 1390637-82-7 |
| 稳定性 | ≥ 2 years |
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