KT 5720
货号：
10011011-500ug 基本售价：
7728.0 元 规格：
500 ug
产品信息
概述| 货号 | 10011011-500ug |
| 描述 | Protein kinase A (PKA) regulates multiple signal transduction events via protein phosphorylation and is integral to all cellular responses involving the cyclic AMP second messenger system. KT 5720 is one of a family of compounds synthesized by the fungus Nocardiopsis sp.. It blocks PKA signaling through competitive inhibition of ATP with a Ki value of 60 nM.1 Reported IC50 values vary widely depending upon ATP concentration tested and can range from 56 nM (low ATP) to 3 µM (physiologic ATP).2,3 Non-specific effects of KT 5720 include inhibition of phosphorylase kinase, PDK1, MEK, MSK1, PKBα, and GSK3β at concentrations as effective as or more potent than that for inhibition of PKA.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kase, H.,Iwahashi, K.,Nakanishi, S., et al. K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochemical and Biophysical Research Communications 142(2), 436-440 (1987).
2.Davies, S.P.,Reddy, H.,Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochemistry Journal 351, 95-105 (2000).
3.Murray, A.J. Pharmacological PKA inhibition: All may not be what it seems. Science Signaling 1(22), (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 537.6 |
| 分子式 | C32H31N3O5 |
| CAS号 | 108068-98-0 |
| 稳定性 | ≥ 1 year |
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