| 货号 | 3114/50 |
| 别名 | 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7 |
| 供应商 | Tocris |
| 生物活性 | Selective PPARγ receptor agonist (EC50 values are 780 and 555 nM at murine and human PPARγ receptors respectively). Displays no activity at PPARα or PPARδ receptors. Antidiabetic agent; exerts potent glucose-lowering effects in insulin-resistant diabetic mice. Displays anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Also inhibits cell growth of hematopoietic cell lines. Inhibits lamellipodia formation and actin polymerization. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 441.54 |
| 分子式 | C24H27NO5S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| CAS号 | 97322-87-7 |
| 参考文献 | Koderaet al (2000) Ligand type-specific interactions of peroxisome-proliferator-activated receptor γ with transcriptional coactivators. J.Biol.Chem. 275 33201. PMID: 10944516. Willsonet al (2000) The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 43 527. PMID: 10691680. Fujimuraet al (1998) Effects of troglitazone on the growth and differentiation of hematopoietic cell lines. Int.J.Oncol. 13 1263. PMID: 9824642. Lee and Olefsky (1995) Acute effects of troglitazone on in vivo insulin action in normal rats. Metabolism 44 1166. PMID: 7666790. |