LLY-507
货号：
16441-25mg 基本售价：
7714.0 元 规格：
25 mg
产品信息
概述| 货号 | 16441-25mg |
| 描述 | SMYD2 is a lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53 and retinoblastoma-associated protein.1,2 LLY-507 is a cell-active, small molecule inhibitor of SMYD2 (IC50 = 15 nM).3 It has been shown to inhibit p53 lysine370 monomethylation in KYSE-150 esophageal squamous cell carcinoma cells stably expressing SMYD2 with an IC50 value of 0.6 µM.3 LLY-507 is >100-fold selective for SMYD2 over a panel of 27 protein methyltransferases and non-methyltransferase targets.3 See the Structural Genomics Consortium (SGC) website for more information. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Abu-Farha, M.,Lambert, J.P.,Al-Madhoun, A.S., et al. The tale of two domains: Proteomics and genomics analysis of SMYD2, a new histone methyltransferase. Molecular & Cellular Proteomics 7(3), 560-572 (2008).
2.Brown, M.A.,Sims, R.J., III,Gottlieb, P.D., et al. Identification and characterization of Smyd2: A split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex. Molecular Cancer 5, 26 (2006).
3.Lee, K.,Lee, J.H.,Boovanahalli, S.K., et al. (Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors. Journal of Medicinal Chemistry 50, 1675-1684 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 574.8 |
| 分子式 | C36H42N6O |
| CAS号 | 1793053-37-8 |
| 稳定性 | ≥ 2 years |
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