Tipranavir
货号：
21028-5mg 基本售价：
7700.0 元 规格：
5 mg
产品信息
概述| 货号 | 21028-5mg |
| 描述 | Tipranavir is a potent, orally bioavailable nonpeptidic HIV aspartyl protease inhibitor (Ki< 1 nM) that prevents cleavage and thus activation of functional HIV cleaved proteins.1,2 Formulations containing tipranavir, in combination with other HIV treatments, are effective against multidrug resistant viruses and are used to treat the progression of HIV infection in patients who have not responded well to initial treatments.3 |
| 别名 | PNU-140690; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Turner, S.R.,Strohbach, J.W.,Tommasi, R.A., et al. Tipranavir (PNU-140690): A potent, orally bioavailable nonpeptidic HIV protease inhibitor of the 5,6-dihydro-4-hydroxy-2-pyrone sulfonamide class. J. Med. Chem. 41(18), 3467-3476 (1998).
2.Thaisrivongs, S. and Strohbach, J.W. Structure-based discovery of Tipranavir disodium (PNU-140690E): A potent, orally bioavailable, nonpeptidic HIV protease inhibitor. Biopoly. 51(1), 51-58 (1999).
3.Llibre, J.M.,Schapiro, J.M. and Clotet, B. Clinical implications of genotypic resistance to the newer antiretroviral drugs in HIV-1-infected patients with virological failure. Clin. Infect. Dis. 50(6), 872-881 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 602.7 |
| 分子式 | C31H33F3N2O5S |
| CAS号 | 174484-41-4 |
| 稳定性 | ≥ 2 years |
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