Ansamitocin P-3
货号：
20538-25mg 基本售价：
7700.0 元 规格：
25 mg
产品信息
概述| 货号 | 20538-25mg |
| 描述 | Ansamitocin P-3 is a microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria.1,2 It binds tubulin (Kd = 1.3 µM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation.3 Ansamitocin P-3 also activates the spindle checkpoint surveillance proteins Mad2 and BubR1, blocking cell cycling during mitosis.3 It inhibits the growth of cancer cells in culture and significantly suppresses the growth of several cancer tumors in mice, prolonging survival time.1,3 |
| 别名 | Antibiotic C-15003P3;Maytansinol butyrate; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ootsu, K.,Kozai, Y.,Takeuchi, M., et al. Effects of new antimitotic antibiotics, ansamitocins, on the growth of murine tumors in vivo and on the assembly of microtubules in vitro. Cancer Res. 40(5), 1707-1717 (1980).
2.Kiso, T.,Fujita, J.-I.,Ping, X., et al. Screening for microtubule-disrupting antifungal agents by using a mitotic-arrest mutant of Aspergillus nidulans and novel action of phenylalanine derivatives accompanying tubulin loss. Antimicrob. Agents Chemother. 48(5), 1739-1748 (2004).
3.Venghateri, J.B.,Gupta, T.K.,Verma, P.J., et al. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at the vinblastine site. PLoS One 8(10), (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥85% |
| 计算分子量 | 635.2 |
| 分子式 | C32H43ClN2O9 |
| CAS号 | 66547-09-9 |
| 稳定性 | ≥ 2 years |
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