| 货号 | 2980/50 |
| 别名 | (2,3-Dihydro-1,4-benzodioxin-6-yl)- |
| 供应商 | Tocris |
| 生物活性 | AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats. Neuroprotective in mice undergoing repeat ketamine anesthesia. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 247.29 |
| 分子式 | C14H17NO3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 215923-54-9 |
| 参考文献 | Huanget al (2016) Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits. Sci.Transl.Med. 8 ra85. PMID: 27334260. Shimazakiet al (2007) Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via the AMPA receptor in rats. Eur.J.Pharmacol. 575 94. PMID: 17727837. O'Neillet al (2004) AMPA receptor potentiators for the treatment of CNS disorders. Curr.Drug Targets CNS Neurol.Disord. 3 181. PMID: 15180479. Nagararjanet al (2001) Mechanism and impact of allosteric AMPA receptor modulation by the ampakine TM CX546. Neuropharmacology. 41 650. PMID: 11640919. |