| 货号 | 3296/50 |
| 别名 | 4-(4-Chlorophenyl)-3-methyl-3-buten |
| 供应商 | Tocris |
| 生物活性 | Reversible TRPA1 channel blocker (IC50 values are 3.1 and 4.5 μM at human and mouse TRPA1 respectively). Blocks cinnameldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo. Also blocks TRPA1 pore dilation (IC50 = 10.3 μM for the inhibition of Yo-Pro uptake). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 209.67 |
| 分子式 | C11H12CINO |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 55224-94-7 |
| 参考文献 | Chenet al (2009) Pore dilation occurs in TRPA1 but not in TRPM8 channels. Mol.Pain 5 3. PMID: 19159452. Taylor-Clarket al (2009) Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Mol.Pharmacol. 75 820. PMID: 19171673. Petruset al (2007) A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol.Pain 3 40. PMID: 18086313. |