| 货号 | 14251-250mg |
| 描述 | Fludarabine phosphate is an injectable form of fludarabine (Item No. 14128).1 Fludarabine is an adenosine deaminase resistant analog of 9-β-D-arabinofuranosyladenine (ara-A) that disrupts ribonucleotide reductase and DNA polymerase in blood cells. It exhibits antiproliferative activity (IC50 = 1.54 μM in an RPMI-8226 myeloma cell line) and triggers apoptosis by increasing Bax and decreasing Bid, XIAP, and survivin expression.2,3 Fludarabine is effective in a number of animal tumor systems including LI210 leukemia, CD8F mammary adenocarcinoma, P388 leukemia, and human LX-1 lung tumor xenograft and displays anti-cancer activity against human hematological malignancies in vivo.1,4,5 |
| 别名 | F-ara-AMP;NSC 312887;NSC 328002; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Spriggs, D.R.,Stopa, E.,Mayer, R.J., et al. Fludarabine phosphate (NSC 312878) infusions for the treatment of acute leukemia: Phase I and neuropathological study. Cancer Research 46, 5953-5958 (1986). 2.Meng, H.,Yang, C.,Ni, W., et al. Antitumor activity of fludarabine against human multiple myeloma in vitro and in vivo. European Journal of Haematology 79(6), 486-493 (2007). 3.Bellosillo, B.,Villamor, N.,Colomer, D., et al. In vitro evaluation of fludarabine in combination with cyclophosphamide and/or mitoxantrone in B-cell chronic lymphocytic leukemia. Blood 94(8), 2836-2843 (1999). 4.Tournilhac, O.,Cazin, B.,Leprètre, S., et al. Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia. Blood 103(1), 363-365 (2004). 5.Rai, K.R.,Peterson, B.L.,Appelbaum, F.R., et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. New England Journal of Medicine 343(24), 1750-1757 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 365.2 |
| 分子式 | C10H13FN5O7P |
| CAS号 | 75607-67-9 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |