| 货号 | 18649-5g |
| 描述 | Diosmetin is a natural O-methylated flavone that is structurally related to luteolin (Item No. 10004161). It reversibly inhibits cytochrome P450 (CYP) isoforms 1A1 and 1B1 in human liver microsomes with Ki values of 89 and 16 nM, respectively.1 It less potently inhibits CYP2C8 and CYP2C9 (Kis = 3.1 and 1.7 µM, respectively).2,3 While diosmetin inhibits CYP1A1 activity, it increases the transcription of the CYP1A1 gene in MCF-7 cells by activating the aryl hydrocarbon receptor when applied at 5 µM.4 Diosmetin also inhibits signaling through the stem cell factor receptor, c-Kit, at micromolar concentrations.5 |
| 别名 | Diosmetol;Luteolin 4-methyl ester; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Androutsopoulos, V.P.,Papakyriakou, A.,Vourloumis, D., et al. Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Bioorganic & Medicinal Chemistry 19(9), 2842-2849 (2011). 2.Quintieri, L.,Palatini, P.,Moro, S., et al. Inhibition of cytochrome P450 2C8-mediated drug metabolism by the flavonoid diosmetin. Drug Metab.Pharmacokinet. 26(6), 559-568 (2011). 3.Quintieri, L.,Bortolozzo, S.,Stragliotto, S., et al. Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro. Drug Metab.Pharmacokinet. 25(5), 466-476 (2010). 4.Ciolino, H.P.,Wang, T.T.Y. and Yeh, G.C. Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity. Cancer Research 58(13), 2754-2760 (1998). 5.Lee, S.J.,Jung, T.H.,Kim, H., et al. Inhibition of c-Kit signaling by diosmetin isolated from Chrysanthemum morifolium. Archives of Pharmacal Research 37(2), 175-185 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 300.3 |
| 分子式 | C16H12O6 |
| CAS号 | 520-34-3 |
| 稳定性 | ≥ 2 years |
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