| 货号 | 10045-50mg |
| 描述 | Numerous analogs of arachidonoyl ethanolamide (AEA, anandamide) potentiate its biological activity.1 This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty acid amide hydrolase (FAAH) within the neurons.2 One of the more potent and selective reuptake inhibitors is UCM707, a 3-furyl arachidonoyl analog. UCM707 has an IC50 of 0.8 µM for the inhibition of tritiated AEA uptake into human U937 cells but has low affinity for FAAH, exhibiting an IC50 value of 30 µM.3 UCM707 also potentiates the biological effects of AEA when co-administered in rats.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Devane, W.A.,Hanus, L.,Breuer, A., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258, 1946-1949 (1992). 2.Deutsch, D.G.,Glaser, S.T.,Howell, J.M., et al. The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase. The Journal of Biological Chemisty 276(10), 6967-6973 (2001). 3.López-Rodriguez, M.L.,Viso, A.,Ortega-Gutiérrez, S., et al. Design, synthesis, and biological evaluation of new endocannabinoid transporter inhibitors. European Journal of Medicinal Chemistry 38, 403-412 (2003). 4.de Lago, E.,Fernandez-Ruiz, J.,Ortega-Gutiérrez, S., et al. UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide. European Journal of Pharmacology 449, 99-103 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 383.6 |
| 分子式 | C25H37NO2 |
| CAS号 | 390824-20-1 |
| 稳定性 | ≥ 1 year |
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