| 货号 | 15113-25mg |
| 描述 | Neprilysin (NEP) and NEP2 are membrane-bound zinc metalloproteases.1,2 Phosphoramidon is a natural and potent inhibitor of NEP and NEP2, with Ki values of 2 nM for both enzymes.3,1 It is also a weak inhibitor of the related zinc metalloprotease endothelin-converting enzyme (Ki = 3.5 µM).4 Phosphoramidon has little or no effect on a variety of other proteases, including trypsin, papain, chymotrypsin, pepsin, and angiotensin-converting enzyme.3 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rose, C.,Voisin, S.,Gros, C., et al. Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin. Biochemistry Journal 363(3), 697-705 (2002). 2.Whyteside, A.R. and Turner, A.J. Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences. FEBS Letters 582(16), 2382-2386 (2008). 3.Suda, H.,Aoyagi, T.,Takeuchi, T., et al. A thermolysin inhibitor produced by actinomycetes: Phosporamidon. J.Antibiot.(Tokyo) 26(10), 621-623 (1973). 4.Turner, A.J. and Murphy, L.J. Molecular pharmacology of endothelin converting enzymes. Biochemical Pharmacology 51(2), 91-102 (1996). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 589.5 |
| 分子式 | C23H32N3O10P • 2Na |
| CAS号 | 164204-38-0 |
| 稳定性 | ≥ 2 years |
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