| 货号 | 17767-50mg |
| 描述 | Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). CE3F4 is an uncompetitive inhibitor of Epac1 activity toward its effector Rap1 in vitro(IC50 = 23 µM) and in cells.1,2. It has no effect on PKA activity. CE3F4 blocks Epac1-induced autophagy in cardiomyocytes stimulated with isoprenaline and blocks the activation of transient receptor potential canonical (TRPC) channels by the Epac activator 8-pCPT.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Courilleau, D.,Bisserier, M.,Jullian, J.C., et al. Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac. The Journal of Biological Chemisty 287(53), 44192-44202 (2012). 2.Brown, L.M.,Rogers, K.E.,McCammon, J.A., et al. Identification and validation of modulators of exchange protein activated by cAMP (Epac) activity: Structure-function implications for Epac activation and inhibition. The Journal of Biological Chemisty 289(12), 8217-8230 (2014). 3.Laurent, A.C.,Bisserier, M.,Lucas, A., et al. Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy. Cardiovascular Research 105(1), 55-64 (2015). 4.Domínguez-Rodríguez, A.,Ruiz-Hurtado, G.,Sabourin, J., et al. Proarrhythmic effect of sustained EPAC activation on TRPC3/4 in rat ventricular cardiomyocytes. J.Mol.Cell Cardiol. 87, 74-78 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 351 |
| 分子式 | C11H10Br2FNO |
| CAS号 | 143703-25-7 |
| 稳定性 | ≥ 2 years |
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