Isofagomine (D-tartrate)
货号：
16137-10mg 基本售价：
6930.0 元 规格：
10 mg
产品信息
概述| 货号 | 16137-10mg |
| 描述 | Isofagomine (D-tartrate) is a competitive inhibitor of human lysosomal β-glucosidase (Ki = 0.016-0.025 µM; IC50 = 0.06 µM).1 By interacting with the catalytic pocket of β-glucosidase it acts as a chemical chaperone that increases the amount of β-glucosidase by stabilizing and/or promoting the folding of the enzyme.2 Isofagomine (D-tartrate) has been shown to increase lysosomal β-glucosidase activity by 2- to 3-fold in mutant N370S Gaucher fibroblasts.1 This compound has been studied in the context of Gaucher disease, a lysosomal storage disorder resulting from substantial deficiency of β-glucosidase and recently identified as a parkinsonism risk factor.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kuriyama, C.,Kamiyama, O.,Ikeda, K., et al. In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorganic & Medicinal Chemistry 16(15), 7330-7336 (2008).
2.Witte, M.D.,Kallemeijn, W.W.,Aten, J., et al. Ultrasensitive in situ visualization of active glucocerebrosidase molecules. Nature Chemical Biology 6(12), 907-913 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 297.3 |
| 分子式 | C6H13NO3 • C4H6O6 |
| CAS号 | 957230-65-8 |
| 稳定性 | ≥ 2 years |
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