| 货号 | 15047-50mg |
| 描述 | Wiskott-Aldrich syndrome proteins (WASPs) regulate the actin cytoskeleton by directly interacting with actin in the Arp2/3 complex.1 As a result, they have essential functions in diverse cellular processes, including phagocytosis, cell motility, and membrane trafficking.2 Wiskostatin is a cell-permeable, selective inhibitor of neural WASP (N-WASP, IC50 = ~ 10 μM).2 It directly associates with the GTPase-binding domain of N-WASP, preventing its activation by Cdc42 and phosphatidylinositol 4,5-bisphosphate.2 By inhibiting N-WASP, wiskostatin interferes with membrane transport, endocytosis, and neurological development.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Leung, D.W.,Morgan, D.M. and Rosen, M.K. Biochemical properties and inhibitors of (N-)WASP. Methods in Enzymology 406, 281-296 (2006). 2.Peterson, J.R.,Bickford, L.C.,Morgan, D., et al. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nature Structural & Molecular Biology 11(8), 747-755 (2004). 3.Guerriero, C.J. and Weisz, O.A. N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. American Journal of Physiology.Cell Physiology 292(4), C1562-C1566 (2007). 4.Welliver, T.P.,Chang, S.L.,Linderman, J.J., et al. Ruffles limit diffusion in the plasma membrane during macropinosome formation. Journal of Cell Science 124(23), 4106-4114 (2011). 5.Wegner, A.M.,Nebhan, C.A.,Hu, L., et al. N-WASP and the Arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses. The Journal of Biological Chemisty 283(23), 15912-15920 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 426.1 |
| 分子式 | C17H18Br2N2O |
| CAS号 | 253449-04-6 |
| 稳定性 | ≥ 2 years |
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