| 货号 | 13038-10mg |
| 描述 | Alkynyl-biotin is a form of biotin with a terminal alkyne group separated by two polyethylene glycol moieties. It is used to add biotin to other molecules bearing an azide group using a copper Cu(I)-catalyzed azide-alkyne cycloaddition reaction. Alkynyl-biotin has been used to add a biotin tag to a range of biochemicals, amino acids, proteins, and nucleotides that have been modified by the addition of an azide group.1,2,3 Alkynyl-biotin can also be used to capture sulfenic acid-modified proteins that have been tagged with the cell-permeable probe DAz-2 (Item No. 13382).4 |
| 别名 | Biotin-PEG2-C4-Alkyne; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.McClatchy, D.B.,Ma, Y.,Liu, C., et al. Pulsed azidohomoalanine labeling in mammals (PALM) detects changes in liver-specific LKB1 knockout mice. J. Proteome Res. 14(11), 4815-4822 (2015). 2.Wu, P.,Lu, M.-x.,Cui, X.-t., et al. A high-throughput-compatible assay to measure the degradation of endogenous Huntingtin proteins. Acta. Pharmacol. Sin. 37(10), 1307-1314 (2016). 3.Zayas, J.,Annoual, M.,Das, J.K., et al. Strain promoted click chemistry of 2- or 8-azidopurine and 5-azidopyrimidine nucleosides and 8-azidoadenosine triphosphate with cyclooctynes. Application to living cell fluorescent imaging. Bioconjug. Chem. 26(8), 1519-1532 (2015). 4.Leonard, S.E.,Reddie, K.G., and Carroll, K.S. Mining the thiol proteome for sulfenic acid modifications reveals new targets for oxidation in cells. ACS Chem. Biol. 4(9), 783-799 (2009). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 468.6 |
| 分子式 | C22H36N4O5S |
| CAS号 | 1011268-28-2 |
| 稳定性 | ≥ 2 years |
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