SB-FI-26
货号：
14191-10mg 基本售价：
6832.0 元 规格：
10 mg
产品信息
概述| 货号 | 14191-10mg |
| 描述 | The fatty acid binding proteins (FABPs) 5 and 7 have been identified as intracellular transporters for the endocannabinoid anandamide.1 They are thought to be required for transport of anandamide through the cytoplasm to the endoplasmic reticulum for degradation by fatty acid amide hydrolase. SB-FI-26 is an α-truxillic acid 1-naphthyl mono-ester derived from incarvillateine (I. sinensis) that inhibits FABP5 binding to NBD-stearate in an in vitro displacement assay with a Ki value of 0.9 μM.2 At 20 mg/kg, i.p., SB-FI-26 has been reported to have antinociceptive and anti-inflammatory effects in several mouse models of pain.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kaczocha, M.,Glaser, S.T. and Deutsch, D.G. Identification of intracellular carriers for the endocannabinoid anandamide. Proceedings of the National Academy of Sciences of the United States of America 106(15), 6375-6380 (2009).
2.Berger, W.T.,Ralph, B.P.,Kaczocha, M., et al. Targeting fatty acid binding protein (FABP) anandamide transporters - a novel strategy for development of anti-inflammatory and anti-nociceptive drugs. PLoS One 7(12), (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 422.5 |
| 分子式 | C28H22O4 |
| 稳定性 | ≥ 2 years |
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