| 货号 | 4310/50 |
| 别名 | Hexahydro-1-[(5-iodo-1-naphthalenyl |
| 供应商 | Tocris |
| 生物活性 | Selective MLCK inhibitor (Ki= 0.3 μM). Exhibits more potent inhibition than ML 9 hydrochloride (Cat. No. 0431) Displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. Inhibits proplatelet formation and stabilization. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 452.74 |
| 分子式 | C15H17IN2O2< |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Meinderset al (2015) Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function. Blood 125 1957. PMID: 25538045. Saitohet al (1987) Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase. J.Biol.Chem. 262 7796. PMID: 3108259. |