| 货号 | 3535/50 |
| 别名 | N-{2-[({4-[(2,2-Dimethylpropanoyl)o |
| 供应商 | Tocris |
| 生物活性 | Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-κB activation and LTB4-induced neutrophil transmigration in vitro. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 456.44 |
| 分子式 | C20H21N2NaO7S |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 150374-95-1 |
| 参考文献 | Hagiwaraet al (2009) Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-κB. Inflamm.Res. 58 198. PMID: 19169649. Iwamotoet al (2009) Protective effect of sivelestat sodium hydrate (ONO-5046) on ischemic spinal cord injury. Interact.Cardiovasc.Thorac.Surg. 8 606. PMID: 19289399. Younget al (2007) Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice. Br.J.Pharmacol. 151 628. PMID: 17471175. Kawabataet al (1991) ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem.Biophys.Res.Commun. 177 814. PMID: 2049103. |