8-iso Prostaglandin E2-d4
货号：
10011321-100ug 基本售价：
6706.0 元 规格：
100 ug
产品信息
概述| 货号 | 10011321-100ug |
| 描述 | 8-iso Prostaglandin E2-d4(8-isoPGE2-d4) contains four deuterium atoms at the hydroxyethyl 3, 3,4, and 4 positions. It is intended for use as an internal standard for the quantification of 8-isoPGE2 by GC- or LC-mass spectrometry. 8-isoPGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation.1 It is a potent renal vasoconstrictor in the rat.1,28-isoPGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively.3 When infused into the renal artery of the rat at a concentration of 4 mg/kg/min, 8-isoPGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.1 |
| 别名 | 8-epiPGE2-d4;8-isoPGE2-d4; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Morrow, J.D.,Minton, T.A.,Mukundan, C.R., et al. Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes. The Journal of Biological Chemisty 269, 4317-4326 (1994).
2.Hoffman, S.W.,Moore, S., and Ellis, E.F. Isoprostanes: Free radical-generated prostaglandins with constrictor effects on cerebral arterioles. Stroke 28, 844-884 (1997).
3.Longmire, A.W.,Roberts, L.J., and Morrow, J.D. Actions of the E2-isoprostane, 8-iso-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor. Prostaglandins 48, 247-256 (1994).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 356.5 |
| 分子式 | C20H28D4O5 |
| 稳定性 | ≥ 1 year |
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