| 货号 | 14004-50mg |
| 描述 | The sirtuin SIRT2 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates.1 It has roles in metabolic diseases, cancer, age-related disorders, and neurodegenerative diseases, potentially including Alzheimer’s, Huntington’s, and Parkinson’s diseases.1,2,3 AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM).4 In culture, it dimishes neuronal cell death induced by mutant huntingtin fragment.4 In addition, AK-7 down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.de Oliveira, R.M.,Sarkander, J.,Kazantsev, A.G., et al. SIRT2 as a therapeutic target for age-related disorders. Front.Pharmacol. 3(82), (2012). 2.Fridén-Saxin, M.,Seifert, T.,Landergren, M.R., et al. Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitors. Journal of Medicinal Chemistry 55, 7104-7113 (2012). 3.Xu, K.,Dai, X.L.,Huang, H.C., et al. Targeting HDACs: A promising therapy for Alzheimer’s disease. Oxid.Med.Cell Longev. 2011, (2011). 4.Taylor, D.M.,Balabadra, U.,Xiang, Z., et al. A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chemical Biology 6, 540-546 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 437.4 |
| 分子式 | C19H21BrN2O3S |
| CAS号 | 420831-40-9 |
| 稳定性 | ≥ 2 years |
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