1-Aminodecylidene bis-Phosphonic Acid (sodium salt)
货号：
13583-10mg 基本售价：
6608.0 元 规格：
10 mg
产品信息
概述| 货号 | 13583-10mg |
| 描述 | Sphingomyelinases catalyze the degradation of cellular sphingomyelin to phosphorylcholine and ceramide. Acid sphingomyelinase has vacuolar activity that is important in a variety of physiological and pathophysiological processes.1,21-Aminodecylidenebis-phosphonic acid (sodium salt) is a potent inhibitor of acid sphingomyelinase (IC50 = 20 nM).3 It completely inhibits dexamethasone-induced apoptosis in HepG2 cells, presumably by preventing the generation of proapoptotic ceramide.3 This compound is more than 5,000 times more selective for acid sphingomyelinase than for the Mg2+-dependent neutral sphingomyelinase (IC50 > 100 μM).3 |
| 别名 | 1-Amindecane-1,1-Diphosphonic Acid; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zeidan, Y.H., and Hannun, Y.A. Activation of acid sphingomyelinase by protein kinase Cδ-mediated phosphorylation. The Journal of Biological Chemisty 282(15), 11549-11561 (2011).
2.Smith, E.L., and Schuchman, E.H. The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases. The FASEB Journal 22, 3419-3431 (2008).
3.Roth, A.G.,Drescher, D.,Yang, Y., et al. Potent and selective inhibition of acid sphingomyelinase by bisphosphonates. Angewandte Chemie International Edition 48, 7560-7563 (2009).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 340.2 |
| 分子式 | C10H25NO6P2 • Na |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
