Tienilic Acid
货号：
10008517-50mg 基本售价：
6496.0 元 规格：
50 mg
产品信息
概述| 货号 | 10008517-50mg |
| 描述 | Cytochrome P450 enzymes function to metabolize both endogenous and exogenous compounds. Both the 3A and 2C isoforms are present in human liver of which CYP2C9 seems most highly expressed.1 Tienilic acid is a specific suicide substrate for CYP2C9 and CYP2C10 whereby its oxidation inactivates the enzyme.2,3 The time required to inactivate one half of the CYP2C10 enzyme at the maximal rate (t½max) is 3.4 minutes, with a dissociation constant (KI) value of 4.3 µM.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mancy, A.,Broto, P.,Dijols, S., et al. The substrate binding site of human liver cytochrome P450 2C9: An approach using designed tienilic acid derivatives and molecular modeling. Biochemistry 34, 10365-10375 (1995).
2.Jean, P.,Lopez-Garcia, P.,Dansette, P.M., et al. Oxidation of tienilic acid by human yeast-expressed cytochromes P450 2C8, 2C9, 2C18 and 2C19: Evidence that this drug is a mechanism-based inhibitor specific of cytochrome P450 2C9. European Journal of Biochemistry 241, 797-804 (1996).
3.Lopez-Garcia, M.P.,Dansette, P.M., and Mansuy, D. Thiophene derivatives as new mechanism-based inhibitors of cytochromes P450: Inactivation of yeast-expressed human liver P450 2C9 by tienilic acid. Biochemistry 33, 166-175 (1994).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥99% |
| 计算分子量 | 331.2 |
| 分子式 | C13H8Cl2O4S |
| CAS号 | 40180-04-9 |
| 稳定性 | ≥ 1 year |
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