INCB 28060
货号：
20056-50mg 基本售价：
6370.0 元 规格：
50 mg
产品信息
概述| 货号 | 20056-50mg |
| 描述 | INCB 28060 is an inhibitor of heptatocyte growth factor receptor (HGFR, also known as c-Met), potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activity in cells (IC50 values range from 0.3 to 1.1 nM).1 It blocks cell proliferation and migration or induces apoptosis in different types of cancer cells.1 INCB 28060 is orally bioavailable and inhibits the growth of HGFR-dependent tumors in mice.1 It also improves efficacy of gemcitabine (Item No. 11690) in a mouse pancreatic cancer model and reduces migration and adhesion in ovarian cancer cell models.2,3 |
| 别名 | Capmatinib;INC 280; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liu, X.,Wang, Q.,Yang, G., et al. A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3. Clin. Cancer. Res 17(22), 127-138 (2011).
2.Brandes, F.,Schmidt, K.,Wagner, C., et al. Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model. BMC Cancer 15:71, (2015).
3.Moran-Jones, K.,Brown, L.M., and Samimi, G. INC280, an orally available small molecule inhibitor of c-MET, reduces migration and adhesion in ovarian cancer cell models. Sci. Rep. 5:11749, (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 412.4 |
| 分子式 | C23H17FN6O |
| CAS号 | 1029712-80-8 |
| 稳定性 | ≥ 2 years |
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