GSK2334470
货号：
18095-50mg 基本售价：
6202.0 元 规格：
50 mg
产品信息
概述| 货号 | 18095-50mg |
| 描述 | 3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that plays an important role in growth factor signaling by phosphorylating and activating a group of kinases, including protein kinase (PK)B, PKA, and certain isoforms of PKC. GSK2334470 is an inhibitor of PDK1 (IC50 = ~10 nM) that even at 100-fold higher concentrations does not affect the activity of 93 other protein kinases, including that of 13 closely related AGC kinase family members.1 In HEK293 cells, 30 nM - 1 µM GSK2334470 suppresses T-loop phosphorylation and activation of SGK, S6K1, and RSK, as well as the activation of Akt.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Najafov, A.,Sommer, E.M.,Axten, J.M., et al. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochemistry Journal 433(2), 357-369 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 462.6 |
| 分子式 | C25H34N8O |
| CAS号 | 1227911-45-6 |
| 稳定性 | ≥ 2 years |
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