R547
货号：
17905-5mg 基本售价：
6174.0 元 规格：
5 mg
产品信息
概述| 货号 | 17905-5mg |
| 描述 | Cyclin-dependent kinases (Cdks) are critical positive regulators of cell cycle progression and cellular transcription whose dysregulation can lead to the development of cancer. R547 is a diaminopyrimidine compound that inhibits Cdk1/cyclin B, Cdk2/cyclin E, and Cdk4/cyclin D1 (Kis = 1-3 nM).1 It is inactive against a panel of more than 120 unrelated kinases (Kis > 5 µM).1 R547 inhibits tumor cell proliferation (IC50s ≤ 0.6 µM in vitro), inducing cell cycle arrest at G1 and G2 phases and apoptosis as well as reducing phosphorylation of the retinoblastoma protein.1 It also demonstrates antitumor activity in vivo in various human tumor xenograft models.1 |
| 别名 | Ro 4584820; |
性能| 供应商 | Cayman |
| 应用文献 |
1.DePinto, W.,Chu, X.J.,Yin, X., et al. In vitro and in vivo activity of R547: A potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials. Molecular Cancer Therapeutics 5(11), 2644-2658 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 441.5 |
| 分子式 | C18H21F2N5O4S |
| CAS号 | 741713-40-6 |
| 稳定性 | ≥ 2 years |
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